Lynette takes extreme measures to protect her son. Carlos realizes the extent of Gaby's sacrifices for their family. Bree wants to prove to Andrew that she has accepted him for who he is. Katherine finds happiness, as Susan and Mike recognize the fate of their relationship. Meanwhile, Dave starts to lose his grip.

For Gaby and Carlos, injuries sustained in the fire lead to a fortunate discovery. But for most, the consequences are less forgiving. Lynette and Tom vow to protect son Porter at any cost. Susan must learn to let go of the man she loves. Orson's attempt at a good night's sleep puts Bree in a most precarious, though amusing, position on the day of her big cooking demonstration.

Susan's daughter Julie (former main castmember Andrea Bowen) comes to visit with her surprising new boyfriend (played by Steven Weber). Gabrielle learns that Mrs. Hildebrand (guest star Frances Conroy) has made her and Carlos heirs of her entire fortune. A reporter looks to expose Bree's imperfections. Lynette learns Porter and Anne Schilling (guest star Gail O'Grady) plan to leave Fairview and disappear. Finally, everyone has gathered at a club to see the guys play in the annual "Battle of the Bands" when a fire erupts, threatening the lives of those in attendance. Some will fall as a hero will rise.

Lynette and Tom uncover the unsettling truth about son Porter. Gabrielle suspects Carlos' best client, Virginia (guest star Frances Conroy), has ulterior motives. Bree's moment of weakness could bring her great embarrassment and shame. Katherine's not-so-little secret is unveiled. Susan learns of Jackson's true passion. Finally, Mrs. McCluskey's sister Roberta (guest star Lily Tomlin) unearths a disturbing fact about Dave.

Gaby is over the moon when Carlos' client makes them an offer they can't refuse, but a startling discovery leaves her second guessing. Lynette grows suspicious that Tom is cheating on her. After breaking up with Jackson, Susan tries to surprise him, only to find the surprise is on her. Meanwhile, the bond between Bree and Katherine grows. Finally, Mrs. McCluskey enlists the help of her sister Roberta (guest star Lily Tomlin) to dig up dirt on Dave.

Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday. Jackson wants to take his relationship with Susan to the next level. Gabrielle's concerned she might be pregnant. Tom tells Lynette he's sold the pizzeria. A startling reason for the bond between Bree and Katherine is revealed. And finally, an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

Bree's new cookbook and entrepreneurial success has the women of Wisteria Lane feeling envious. Lynette's longing for a taste of her breadwinning days as an ad-exec leads her to lend an unsolicited hand to Bree's marketing plan. MJ's drawing of a family portrait has left Mike feeling like he's not a presence in his son's life. Gaby hatches a plan to have more sex with Carlos. Susan teaches a reluctant MJ how to fall. Meanwhile, Dave's motives for moving to the neighborhood continue to take shape.

Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism. Meanwhile, Gabrielle and Susan find themselves embroiled in a catfight brought on by an altercation between their kids. To her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things. Finally, Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.

Lynette discovers her son, Porter, has a softer side, which she finds endearing. Gaby amusingly attempts to mask her demise in social stature. The time has come for the men in Susan's life to meet. Meanwhile, Bree begins to feel the pressures of balancing marriage and a career. Edie is reminded just how hostile the neighbors on Wisteria Lane can be. Finally, a suspicious Mrs. McCluskey enlists Katherine's help to uncover more about their new neighbor, Dave.

On the highly anticipated season five premiere, five years have passed since Katherine shot her ex-husband as Susan, Lynette, Bree and Gabrielle stood together in solidarity to protect her. Susan tries to hide her relationship with a new man. Gaby questions her abilities as a mother. Bree is on the verge of publishing her own cookbook as business partner Katherine grows envious. Lynette catches her teenaged twins spearheading illegal activities. And finally, Edie returns to Wisteria Lane in jaw-dropping fashion with a new man in tow, her new husband Dave (played by Neal McDonough).